My current primary interest concerns clinical trial design and the development of data analytic methods for informing multi-stage decision making in health. In particular for (1) constructing individualized sequences of treatments (a.k.a., adaptive interventions) for use in informing clinical decision making and (2) constructing real time individualized sequences of treatments (a.k.a., Just-in-Time Adaptive Interventions) delivered by mobile devices. See Workshop on Just in Time Adaptive Interventions. This is Precision Medicine. Adaptive Interventions are composed of a sequence of decision rules that specify when to alter the therapy and specify which intensity or type of subsequent therapy should be offered. The decision rules employ variables such as patient response, risk, burden, adherence, and preference, collected during prior therapy. These regimes hold the promise of maximizing treatment efficacy by avoiding ill effects due to over-treatment and by providing increased treatment levels to those who can benefit.
My work has been funded by
National Institute on Drug Abuse and by National Institute of Mental Health.
I work with researchers at
The Methodology Center on these topics.